Modafinil is a central nervous system stimulant developed in the 70s and then licensed for use in the 90s. It is sold under the brand name Provigil among others and available as a generic medication. Generic medications have the same active ingredients as branded medications, however the pharmaceutical companies who manufacture them did not invest the same amount of time and money into the development of the medication. This is why generic medications are usually available at much lower prices.

Modafinil tablets are used to treat a range of conditions, including narcolepsy, attention deficit hyperactivity disorder (ADHD), and for cognitive enhancement, which we will describe in more detail now. Narcolepsy is a rare condition which causes people to suddenly fall asleep in the day and unexpectedly lose muscle tone and collapse. The condition is thought to be caused by the body’s own cells mistakenly attacking the receptors in the brain which secrete a neurotransmitter called hypocretin, which promotes wakefulness. ADHD is a condition which have symptoms including the inability to concentrate, spontaneous behaviour, and reduced capacity for learning.

Although there is no cure for narcolepsy or ADHD, you can buy modafinil to help manage the symptoms. Some people use modafinil for studying as it can increase concentration, memory, and wakefulness, which is useful during exam periods or for completing assignments. It is also used off label for the management of obstructive sleep apnoea and shift-work sleep disorder.

Modafinil Mechanism of Action

Modafinil is thought to primarily target dopamine receptors, however the specific mechanism of action is not fully understood. It is well accepted that the medication is a central nervous system stimulant. The central nervous system consists of the brain and the spinal cord, and there is an abundance of cells within the brain which are called neurons. Neurons communicate via signals within the brain, to the peripheral nervous system and the rest of the body. In between neurons are tiny gaps called synapses, and it is here that a lot of receptors are located.

When the medication binds to the dopamine receptors this stimulates them to produce and secrete the neurotransmitter dopamine while also preventing the reuptake of it. Dopamine is an excitatory neurotransmitter, and it results in increased concentration and motivation. Modafinil pills also indirectly increase the production of hypocretin which improves wakefulness.

Modafinil Duration of Action

So, how long does modafinil last? It is absorbed rapidly via the gastrointestinal (GI) tract, where it passes into the blood stream and crosses the blood brain barrier. It has a high bioavailability of over 80% and the level of absorption isn’t altered if you take it on an empty stomach or with food. You will start to feel the modafinil effects after about 1 hour and it reaches peak plasma concentration after 2 to 3 hours. The modafinil half-life is between 10 and 12 hours, however this can vary due to factors such as your body mass index (BMI) and your metabolism.

The elimination half-life is the amount of time it takes for half of the medication to be metabolised and eliminated from your body, so it will still be detected for at least twice the amount of that time. You can read reviews with anecdotal evidence of how it feels and buy modafinil online from our UK based pharmacy.

Dosage Instructions for Modafinil

The exact modafinil dosage will vary depending on which condition it is being used to treat. The maximum daily dosage will also be different for different disorders but should never exceed 400 mg. Modafinil 200 mg is the usual starting dose for most conditions. If you are taking it for narcolepsy or ADHD, you will usually have 1 tablet in the morning and another in the afternoon. If you are taking modafinil for studying, then you should take it about an hour before you need it to start working. Tablets should always be swallowed whole with a glass of water and never crushed at all.

Modafinil 200 mg can be taken whole or split in half and taken as 2 doses. If you are taking multiple doses throughout the day, then you should ensure that you space the doses out evenly throughout the day.

Always take Modafinil Tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Tablets should be swallowed whole with water.
Adults: The usual dose is 200mg a day. This can be taken once daily (in the morning) or divided into two doses a day (100mg in the morning and 100mg at midday). Your doctor in some cases may decide to increase your daily dose up to 400mg.
Elderly patients (over 65 years of age): The usual dose is 100mg a day.
Your doctor will only increase your dose (up to the maximum 400mg a day) provided that you do not have any liver or kidney problems.
Adults with severe kidney and liver problems: The usual dose is 100mg a day.
Your doctor will review your treatment regularly to check that it is right for you.
If you take more Modafinil Tablets than you should : if you take too many tablets you may feel sick, restless, disorientated, confused, agitated, anxious or excited. You may also have difficulty sleeping, diarrhoea, hallucinations (sensing things that are not real), chest pain, a change in the speed of your heartbeat or an increase in blood pressure.

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