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JWH-018 or Spice (spice, K2, translated from English. – “seasoning, spice”) is one of the brands of smoking mixtures sold in the form of herbs with applied chemical substances. Has a psychoactive effect somewhat similar to that of marijuana, but causing more severe psychopathological symptoms. Like marijuana, Spice acts on the cannabinoid receptor. In case of acute intoxication with the Spice drug, derealization, and depersonalization disorders, disorders of space perception, disturbances in the body scheme, synesthesia can occur – which can continue in a mild form even a month after administration. The world is perceived as unfamiliar, alienated, “consciousness leaves the body,” sometimes psychomotor agitation with the effect of anxiety or fear. The sale of Spice mixtures has been carried out in European countries since 2006 (according to some sources – since 2004) under the guise of incense, mainly through online stores. In 2009, it was found that the active ingredient in the mixtures is not herbal substances, but synthetic analogs of tetrahydrocannabinol, the main active ingredient in marijuana, such as CP 47,497 and JWH-018. Currently, synthetic cannabinoids, which are the active ingredients of Spice, are banned in most countries of the world, including Russia, the USA, and many countries of the European Union.
Usage of JWH-018
At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.
On October 15, 2011, Anderson County coroner Greg Shore attributed the death of a South Carolina college basketball player to “drug toxicity and organ failure” caused by JWH-018. An email dated Nov 4, 2011, concerning the case was finally released by the city of Anderson S.C. on Dec 16, 2011, under the Freedom of Information Act after multiple requests by media to see the information had been denied.
Compared to THC, which is a partial agonist at CB1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. THC has been shown to inhibit GABA receptor neurotransmission in the brain via several pathways. JWH-018 may cause intense anxiety, agitation, and, in rare cases (generally with non-regular JWH users), has been assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess.
Various physical and psychological adverse effects have been reported from JWH-018 use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation. Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.
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