Buy Exemestane (Aromasin) online by Natco Pharma
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Buy Post Cycle Therapy(PCT) pen of Aromasin is a most popular Steroid available without prescription.
The following pharmacological and medical categories are available:
Drugs that are anticancer
Agents that are antineoplastic
Inhibitors of aromatase
Chemotherapy with hormones
Breast cancer medications
ER-positive cancer treatments
Aromatase inhibitors that are nonsteroidal
Medicines for cancer
Pharmaceuticals for sports and bodybuilding
Inhibitors of steroidal aromatase
ATC codes for women’s health:
L – Antineoplastics and immunomodulators
Endocrine therapy – L02
Hormone antagonists and related agents – L02B
L02BG – Aromatase inhibitors
L02BG06 – Exemestane
The aromatase inhibitor Aromasin (Exemestane) is prescribed for malignant neoplasms of the breast.
Treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to Aromasin for completion of five consecutive years of adjuvant hormone therapy.
The treatment of postmenopausal women with advanced breast cancer who have received tamoxifen therapy.
Exemestane 25 mg is recommended to be taken after meals once daily.
Overdosage: Exemestane has been given as a single dose to healthy female volunteers at doses up to 800 mg a day, and daily for 12 weeks to postmenopausal women with advanced breast cancer at doses up to 600 mg a day. Tolerance of these dosages was good. Overdosage has no specific antidote, and treatment must be symptomatic. There should be close observation of the patient as well as monitoring of their vital signs.
It has been reported that a male child (age unknown) accidentally ingested an exemestane 25-mg tablet. The initial physical examination was normal, but blood tests performed 1 hour after ingestion indicated leukocytosis (WBC 25000/mm3 with 90% neutrophils). Blood tests were repeated 4 days after the incident and were normal. No treatment was given.
A single oral dose of 3200 mg/kg of exemestane killed mice (about 640 times the human dose based on mg/m2), the lowest dose tested. Several animal studies have shown mortality following oral administration of exemestane at doses of 5000 mg/kg (about 2000 times the recommended human dose based on mg/m2) and 3000 mg/kg (about 4000 times the recommended human dose based on mg/m2).
A single dose of 400 mg/kg and 3000 mg/kg exemestane caused convulsions in mice and dogs (about 80 and 4000 times the recommended human dose, respectively).
Dosage forms and strengths:
Aromasin (Exemestane) tablets 25 mg.
Patients with a known hypersensitivity to the drug or to any of the excipients.
Warnings and precautions:
There is a decrease in bone mineral density (BMD) with exemestane use over time.
Prior to beginning treatment with an aromatase inhibitor, routine measurement of 25-hydroxyvitamin D should be conducted.
Toxicology of pregnant women: can damage the developing fetus. Women of reproductive potential should be informed about the potential risk to a fetus and encouraged to use effective contraception.
Adverse reactions, side effects:
Hot flushes, fatigue, arthralgia, headache, insomnia, sweating, and fatigue are adverse reactions that occur in >= 10% of early breast cancer patients. Aromasin and tamoxifen had similar rates of discontinuation due to adverse events. The rates of cardiac ischemic events (myocardial infarction, angina, and myocardial ischemia) were 1.6% and 0.6% respectively for exemestane and tamoxifen. There was a 0.4% cardiac failure rate with Aromasin (Exemestane) and a 0.3% cardiac failure rate with Tamoxifen (6, 6).
Advanced breast cancer: most common adverse reactions were mild to moderate and included hot flushes, nausea, fatigue, increased sweating, and increased appetite.
Please contact your local FDA or Pfizer Inc. to report suspected adverse reactions.
Inducers of CYP3A4: concurrent use of inducers of CYP3A4 decreases exposure to exemestane. The dose of Aromasin (Exemestane) should be increased to 50 mg.
Use in specific populations: Lactation Advise against breastfeeding.
It is not yet known whether this drug is safe and effective for children.
Children with severe or moderate hepatic impairment (Childs-Pugh B or C) had a higher AUC of exemestane. Despite this, dosage adjustment does not appear to be necessary based on experience with exemestane at repeated doses up to 200 mg daily that demonstrated a moderate increase in non-life-threatening adverse reactions.
The AUC of exemestane was elevated in subjects with moderate or severe renal impairment (creatinine clearance < 35 mL/min/1.73 m2). It appears that exemestane dosage needs not be adjusted based on experience with repeated doses of 200 mg daily that demonstrated an increase in non-life-threatening adverse reactions.
C – Australia
D – United States (Positive evidence of risk)
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Manufacturer: Natco Pharma
Category: Buy Post Cycle Therapy(PCT)